• thiostrepton br Conclusion In this study we have successfull

  2018-10-24

  

  Conclusion In this study we have successfully generated iPSCs, and iPSC-derived retinal organoids, from patients with TRNT1-associated RP and used these thiostrepton to investigate the underlying pathophysiologic mechanisms of disease. We have also identified disease-specific phenotypes that prov

• Finally we suggest a potential mode of action

  2018-10-24

  

  Finally, we suggest a potential mode of action for the observed neuroprotective effects following grafting of IL-13-producing MSCs. Based on our data, and in agreement with current literature, we can put forward two mechanistic explanations. Firstly, it has been shown that a reduction in CX3CR1 sign

• br Experimental Procedures br Author Contributions br

  2018-10-24

  

  Experimental Procedures Author Contributions Acknowledgments This work was funded by CRUK (grant A10065). A.P. and H.W. thank Worldwide Cancer Research for support (grant 13-0146). Introduction Cancer stem gallic acid (CSCs) generally account for a rare subpopulation of cells within tum

• br Results br Discussion Experimental transdifferentiation

  2018-10-24

  

  Results Discussion Experimental transdifferentiation of ldv by ectopic expression of conditional C/EBPα has shed light on the molecular dynamics of the conversion of lymphoid cells into inflammatory macrophages (Bussmann et al., 2009; Di Tullio et al., 2011; Krijger et al., 2016; Laiosa et al

• Lastly the question remains of why teleost

  2018-10-24

  

  Lastly, the question remains of why teleost retinas have maintained a robust regenerative response while mammalian retinas are largely incapable of repair. The cellular organization found in zebrafish may be a key difference. In zebrafish, the HCs form a monolayer that is separated from the rest of

• Inflammation is one of the main features of

  2018-10-24

  

  Inflammation is one of the main features of neurodegenerative diseases (Campbell, 2004). Having methods available that generate human astrocytes that are responsive to inflammation allows for the modeling of this component of the disease using patients\' cells. Previous studies reported the generati

• Future studies of human astrocyte response to inflammation

  2018-10-24

  

  Future studies of human astrocyte response to inflammation require reliable in vitro models. Human astrocytes can be cultured from fetal and adult biopsies; however, the availability of CNS human tissue is reduced and immunopanning is required to obtain pure astrocyte preparations (Zhang et al., 201

• br The technical characteristics of the equipment used for

  2018-10-24

  

  The technical characteristics of the equipment used for solving the problems that arise in studying various processes and phenomena occurring in the geosphere, such as the nature of the emergence and development of crustal deformation variations, are of high importance. Laser deformographs of diff

• br Methods br Results Table

  2018-10-24

  

  Methods Results Table 1 below presents baseline characteristics for intervention and matched control districts in 2010, the year before PBF began. While there are some differences in population size and the number of primary health facilities in matched districts, the number of facilities per

• Most of the literature that

  2018-10-24

  

  Most of the literature that explicitly include measures of spouses’ resources examine mortality and do not account for the fact that illnesses may affect couples differently depending on spouses’ resources, cf. Monden et al. (2003) and Monden (2007). Our contribution to the literature is thus threef

• The results in Table reveal that

  2018-10-23

  

  The results in Table 2 reveal that the cardinality-constrained portfolios outperform the benchmark index in all cases. For instance, under daily re-balancing frequency the minimum variance portfolio with 3, 5 and 10 assets deliver statistically lower portfolio risk (1.209, 1.120, and 0.956, respecti

• Trunk type origin was from

  2018-10-23

  

  Trunk type origin was from the greater saphenous vein in 67 of 116 patients (58%), from the smaller saphenous vein in 7 (6%), and from both in two (2%). Perforator type origin was from the calf in 36 (31%), the thigh in 6 (5%), and from both in 5 (4%). In 16 patients (14%) the glycogen phosphorylase

• Interestingly the acute onset of myofiber necrosis provides

  2018-10-23

  

  Interestingly, the acute onset of myofiber necrosis provides a good model to study therapeutic interventions designed to prevent or reduce necrosis, since a reduction in dystropathology is easily identified (Grounds and Torrisi, 2004; Radley and Grounds, 2006; Shavlakadze et al., 2004; Stupka et al.

• Geneticists from Guangzhou China recently

  2018-10-23

  

  Geneticists from Guangzhou, China recently shocked the scientific community by publishing what appears to be the first attempt at using CRISPR–Cas9 genomic-editing technology to modify disease-associated DNAs from human embryos. The article appeared in the May 2015 issue of . Despite the enormous

• Disclosure br Acknowledgments br A critical knowledge gap in

  2018-10-23

  

  Disclosure Acknowledgments A critical knowledge gap in the field of HIV cure research is how best to measure the persistence of replication-competent HIV in the form of intact but latent proviruses. One approach to curing HIV is to eradicate all replication-competent HIV from an individual. It

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