• A substantial part of the value of

  2019-05-23

  

  A substantial part of the value of setting goals, targets, and indicators lies in the imperative to collect information for measurement and accountability —“what gets measured gets done”. The decision to exclude an indicator because it chemokine receptor is less established is diametrically opposed

• Air pollution also has a substantial effect on

  2019-05-23

  

  Air pollution also has a substantial effect on the wellbeing of people worldwide. This pollution can consist of sulfur dioxide, ozone, nitrogen dioxide, and fine-particulate vorapaxar of less than 2·5 μm in diameter (PM). 92% of the global population is exposed to higher-than-recommended concentrat

• Introduction Verapamil sensitive idiopathic left ventricular

  2019-05-23

  

  Introduction Verapamil-sensitive idiopathic left ventricular tachycardia (ILVT) has been shown to be a clinical entity of left-sided idiopathic ventricular tachycardia (VT) [1,2]. In electrophysiological studies, two specific local potentials, the diastolic Purkinje (Pd) potential and presystolic P

• It s springtime for surgery declared Meena

  2019-05-23

  

  “It\'s springtime for surgery!” declared Meena Cherian at the launch of the at the end of April. It certainly seems so. In a few days\' time, WHO Member State representatives will gather at the 68th World Health Assembly to discuss, among other things, the adoption a on surgical care and anaesthes

• PXD 101 br Drug resistance In clinical practice

  2019-05-23

  

  Drug resistance In clinical practice, there is no cross–drug-resistance between As2O3 and RA or other antileukemic agents. This may be explained by the non-liposoluble nature of As2O3, its small molecular weight, and its distinctive modes of action [20]. In our observation, primary As2O3 resistan

• br The study by Jesse

  2019-05-23

  

  The study by Jesse Berman and colleagues published in is the first to systematically analyse the risk of hospital admissions and mortality associated with drought periods in the USA. As the authors state, this is an understudied topic, but of great concern in the USA and globally as climate change

• Birinapant The starting point is to address the huge gap in

  2019-05-23

  

  The starting point is to address the huge gap in surveillance capabilities identified in 2014 by the WHO\'s first global report on surveillance of antimicrobial resistance. To address this Birinapant gap, WHO\'s action plan is being implemented in phases from early 2016 onwards, gathering informati

• The ETV ABL fusion has

  2019-05-22

  

  The ETV6-ABL1 fusion has been reported as a poor prognostic factor when found in acute leukemia (AML and ALL) and MDS. The prognostic significance of an ETV6/ABL1 chronic myeloproliferative neoplasm is less clear due to the paucity of cases and the lack of controlled clinical trials [5]. There is a

• On the basis of this mechanism the prolonged RR

  2019-05-22

  

  On the basis of this mechanism, the prolonged RR interval with the patient\'s symptoms was likely a reflection of the progression of the AV block with an underlying first-degree AV block. Despite a first-degree AV block (420ms) during the short RP rhythm, a short PR interval (160ms) was observed wit

• Eastern European countries have undergone many socioeconomic

  2019-05-22

  

  Eastern European countries have undergone many socioeconomic changes in the past two decades. In particular, in Russia, alcohol was strongly associated with adult mortality. More than half of deaths in Russian men are attributable to cardiovascular disease, with hypertension, hypercholesterolaemia,

• br Identidade negra e quilombola O uso da

  2019-05-22

  

  Identidade negra e quilombola O uso da expressão “remanescentes” para classificar os agrupamentos negros, enquanto unidades que guardam correspondência histórica com os quilombos, motivou reflexões sobre seu significado. Adotamos o entendimento de que ao contrário do sentido de sobra ao qual pode

• br Una de las m s acres y reiteradas recriminaciones

  2019-05-22

  

  Una de las más acres y reiteradas recriminaciones gingerol la tl provenientes de los sectores eclesiales más conservadores, ha estado fundada en el uso del instrumental teórico de origen marxista y su tesis de la lucha de clases, debido a que se le atribuye una irreconciliable incompatibilidad con

• br Conclusion br Introduction Multiple myeloma is

  2019-05-22

  

  Conclusion Introduction Multiple myeloma is a malignant plasma cell disorder, comprising approximately 10% of all haematological malignancies, and its incidence is increasing [1]. The pathogenesis is complex, culminating in malignant transformation of clonal plasma cells. The aetiology is not

• adenosine receptor br Other candidate genes br The

  2019-05-22

  

  Other candidate genes The frequency of minor gene mutations in BrS As mentioned above, more than 10 genes have been reported to cause BrS. The proportions of BrS patients who are mutation carriers, however, are very small, except in the case of SCN5A. In a recent extensive mutation analysis of

• We observed a downregulation of several

  2019-05-22

  

  We observed a downregulation of several thyroid-related genes such as DUOX1, DUOX2, TG, and TSHR. This may appear counterintuitive given that dedifferentiation typically worsens patient outcomes. However, it is noteworthy that there was no difference in the pak4 of SLC5A5 (sodium-iodide symporter),

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