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Heating of aluminium alloy at high temperature results in di
2018-11-15
Heating of aluminium alloy at high temperature results in diffusing Si out of the lattice [25]. Since Si–Ag is an eutectic system which is practically immiscible in solid state, the diffusion of Si across the silver interlayer is restricted, resulting in higher concentration of Si at interface of a
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Finally the technological cutting edge of
2018-11-14
Finally, the technological cutting edge of postwar concrete involved the use of thin shells. Much of the excitement about postwar modern architecture can be credited to elegant lightness achieved by engineers like Pier Luigi Nervi and Felix Candela (Figure 5). Such shell structures arrived relativel
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There is a significant need to develop novel therapeutics to
2018-11-14
There is a significant need to develop novel therapeutics to counter BoNT poisoning—especially postneuronal internalization (Hakami et al., 2010). However, there are currently no reliable, large-scale cell-based drug screening assays to facilitate such research. This is mainly due to a lack of relev
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Cell motility is a complex physicochemical process
2018-11-14
Cell motility is a complex physicochemical process that leads to the translocation of the metabotropic glutamate receptor across two-dimensional (2D) surfaces, through basement membranes, or through three-dimensional (3D) interstitial tissues (Ridley et al., 2003). During cell movement through base
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Herein we describe increased VEGFA and SEMA A expression
2018-11-14
Herein, we describe increased VEGFA and SEMA3A expression in bone marrow dihydrofolate reductase from de novo AML patients and the possible dominant effect of SEMA3A, suggesting that SEMA3A could control the effects caused by VEGFA. However, some questions remain: Why is SEMA3A expression increased
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br Gut Damage in Conditions Other
2018-11-14
Gut Damage in Conditions Other Than HIV: Learning From “Outside the Box” Early in the HIV pandemic, GI dysfunctions were reported in patients progressing to AIDS. These dysfunctions included nutrient malabsorption, diarrhea and weight loss, all of which pointed to a link between the disruption of
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Glucose intolerance and impaired insulin
2018-11-14
Glucose intolerance and impaired insulin signaling in adipose tissue was detected only after several weeks of HFD, but not chow diet, in hLRP1-KO mice. This indicates that the HFD may progressively worsen the LRP1 deficiency-induced pure hepatic insulin resistance and further reduce insulin clearanc
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The racial disparity in US rates of cancer among
2018-11-14
The racial disparity in US rates of cancer (among other diseases) has been well-characterized and continues to persist with African-Americans having generally worse cancer incidence and mortality than Whites (). While many researchers have identified proximal causes for this disparity current resear
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Protein tyrosine phosphatases PTPs are inactivated
2018-11-14
Protein tyrosine phosphatases (PTPs) are inactivated by ROS-catalyzed sulfenylation at the conserved motif HC(X)5RS/T, since this motif overlaps with the substrate binding site of PTPs and this sulfenylation interrupts the binding with substrate (Fig. 4E). PP2Ac has a motif of HC(X)4EXV that is simi
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Statins hydroxy methylglutaryl coenzyme A HMG CoA reductase
2018-11-14
Statins, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, include lovastatin, simvastatin, mevastatin, fluvastatin, pravastatin, atorvastatin, rosuvastatin and cerivastatin. Statins have been widely used for lowering cholesterol, but recent research reveal other roles, such as a
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br Acknowledgements This work was sponsored
2018-11-14
Acknowledgements This work was sponsored by the Rathbone Wine Group, the University of Melbourne, the Australian Wine Research Institute (AWRI), and the Australia Grape and Wine Authority. The work was performed at the University of Melbourne and AWRI and was supported by Australia׳s grape grower
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br Data Reported data represents the
2018-11-14
Data Reported data represents the observed association between use of injectable insulin preceding breast cancer and the growth factor profiles at the time of cancer diagnosis in women with diabetes mellitus (Table 1). Data in Table 2 includes the observed correlations between growth factors stra
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Fig Right side shows that the percent habituation
2018-11-13
Fig. 1 (Right side) shows that the percent habituation in stage 5 patients differed from controls at the 250ms and 500ms intervals, but was restored to control levels by bilateral pallidotomy. We speculated that the increased PPN output in PD was instantly re-inhibited or down regulated by the surge
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br Discussion The overnight monitoring for adverse events mi
2018-11-13
Discussion The overnight monitoring for adverse events might be sufficient in these cases. Gupta et al. demonstrated in their study the risk of respiratory complications were high on the day one [12]. They have shown an increased risk of postoperative complications (39% vs 18%), higher rate of t
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br Experimental section br Results and
2018-11-13
Experimental section Results and discussion Building upon our previous work, we developed a water-stable sensor using rGO as the semiconducting channel material and Au NPs as the modular attachment points for immobilizing the probes [7]. This sensor enabled real-time sensing for in situ underw
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