• br Materials and methods br

  2018-11-08

  

  Materials and methods Results Discussion Strategies aiming at controlled divergence of ASCs to specific differentiated cell types essentially rely on prolonged culture in the presence of specific sets of growth factors and/or matrix proteins (Zuk et al., 2001). Specific culture conditions w

• Introduction The mechanisms by which pluripotency regulators

  2018-11-08

  

  Introduction The mechanisms by which pluripotency regulators dictate self-renewal versus differentiation are only recently being studied (Wagner et al., 2010; Niwa et al., 2009). In addition, various approaches are being developed to examine such processes (Wang et al, 2013). The transcriptional re

• Aside from phenotypic differences functional

  2018-11-08

  

  Aside from phenotypic differences, functional differences have also been described between adult BM and FL LT-HSCs (Higuchi et al. 2003; Bowie et al. 2007). For instance, FL LT-HSCs display significantly faster expansion kinetics when grafted in adult mice, compared with LT-HSCs from BM of 8-week-ol

• BSS PBMC iPS F expressed the endogenous pluripotent transcri

  2018-11-08

  

  BSS1-PBMC-iPS4F4 expressed the endogenous pluripotent transcription factors OCT3/4, SOX2, REX1 and NANOG, assessed by RT-PCR (Fig. 2A) and the protein pluripotent markers SSEA3, SSEA4, Tra1–60, Tra1–81 and Oct3/4, evaluated by flow cytometry analysis (Fig. 2B). To demonstrate the capacity of BSS1-PB

• Introduction Osteoprogenitor cells are ubiquitous multipoten

  2018-11-08

  

  Introduction Osteoprogenitor cells are ubiquitous, multipotent stromal cells capable of differentiating into multiple cellular lineages [e.g. osteoblasts (responsible for secretion of the extracellular bone matrix) and osteocytes (mature bone cells)], and replenish existing local cell populations (

• The elevation of JAG surface expression in

  2018-11-08

  

  The elevation of JAG1 surface expression in transitional ECs suggests that it plays a role in phenotypic transition of these cells. Overexpression of activated JAG1 cDNA in cultured human microvascular ECs activated a SMA-promoter driven luciferase and induced trans-differentiation to vascular smoot

• By continuously observing hundreds of individual HSCs

  2018-11-08

  

  By continuously observing hundreds of individual HSCs and their progeny during differentiation, we can exclude a change in cell-cycle length in HSPCs upon GADD45G expression, which was unexpected, because studies on solid tissue Tenofovir Disoproxil Fumarate reported a G2/M cell-cycle arrest mediat

• br Results br Discussion Direct

  2018-11-08

  

  Results Discussion Direct reprogramming of human somatic cftr channel into functional neurons has been proposed as an alternative strategy to obtain patient-specific neurons for disease modeling, drug screening, and toxicity tests (Qiang et al., 2014). Indeed, this approach offers some advanta

• Previously our group has isolated human embryonic stem cells

  2018-11-08

  

  Previously, our group has isolated human embryonic stem K03861 Supplier (ESCs) whose pluripotent state is maintained in vitro by exogenous growth factor signaling, particularly fibroblast growth factor (FGF), insulin or insulin-like growth factor, and transforming growth factor (Bendall et al., 200

• To determine whether overexpression of Sca

  2018-11-08

  

  To determine whether overexpression of Sca-1 in progenitor cells residing in the bulge and upper isthmus could function as an initiating event, Rosa:Cre mice and control littermates were treated with TPA only. This treatment resulted in very few papillomas that quickly regressed and there was no sig

• br Introduction The adult prostate gland contains a simple c

  2018-11-08

  

  Introduction The adult prostate gland contains a simple columnar epithelium composed of luminal secretory and underlying basal XL 184 with a scarce neuroendocrine cell component. These epithelial cells are derived from a rare, relatively quiescent stem cell population that maintains glandular ho

• miRNAs are known to regulate the expression of multiple targ

  2018-11-08

  

  miRNAs are known to regulate the expression of multiple targets via binding to 3′ UTR. Our finding that the miR-29 family regulates global DNA methylation and demethylation adds another role to the list of common regulatory roles of miRNAs. The miR-29 family was known to regulate ECM proteins in phy

• miRNAs often take part in fine tuning major signaling pathwa

  2018-11-07

  

  miRNAs often take part in fine-tuning major signaling pathways (Inui et al., 2010). The interaction between Notch signaling and an miRNA, namely miR-9a, was first described in Drosophila in the context of sensory organ precursor development (Li et al., 2006). More recently, the existence of an inter

• br Introduction Newborn neurons are

  2018-11-07

  

  Introduction Newborn neurons are continuously generated throughout life in several areas of the mammalian brain, including the subgranular zone (SGZ) of the hippocampal dentate gyrus (Imayoshi et al., 2008; Palmer et al., 1997; Zhao et al., 2008). Adult hippocampal neurogenesis is essential for n

• Ara jo et al highlights that the progressive

  2018-11-07

  

  Araújo et al. (1992) highlights that the progressive targeting of the Brazilian MT exports in the late 1980s towards developed countries such as USA, Germany, Italy and Canada shows that the industry made ​​a significant competitive effort. The growth of the intra-industry trade, the diversification

15741 records 1031/1050 page Previous Next First page 上5页 10311032103310341035 下5页 Last page