• There are several reports that demonstrate roles

  2018-10-22

  

  There are several reports that demonstrate roles for Rad51 in addition to its participation in classical HR-mediated DSB repair. For example, in Saccharomyces cerevisiae that lack telomerase or certain telomere binding proteins, the telomeres can be maintained in rare survivors by alternative recomb

• One group has recently identified bone marrow BM residing ve

  2018-10-22

  

  One group has recently identified bone marrow (BM)-residing very small embryonic-like stem cells (VSELs) in both human and mouse as a putative nonembryonic source for PSCs (Drukała et al., 2012; Kucia et al., 2006b; Wojakowski et al., 2009; Zuba-Surma et al., 2011). Mouse VSELs have been characteriz

• To further determine the generality

  2018-10-22

  

  To further determine the generality of our finding that iPSCs harbor unique transversion-predominant point mutation profiles (Figure S2D, left), we analyzed previously reported point mutation profiles in 27 different iPSC lines that had been established by various methods, including retrovirus, plas

• The following are the supplementary data related to this art

  2018-10-22

  

  The following are the supplementary data related to this article. Acknowledgments The work in the author\'s laboratory is currently supported by the grants from NIH (GM093335), New York State (NYSTEM Contract# C026434) and American Heart Association (09SDG2400151). YS is partly supported by NIH

• The ubiquitously expressed FGF is the prototypic member

  2018-10-20

  

  The ubiquitously expressed FGF2 is the prototypic member of the paracrine group of human FGFs (Beenken and Mohammadi, 2009). Its endogenous expression is regulated at multiple levels including the alternative translation of polypeptides that eventually differ in size (18–34kDa), domain structure and

• Moreover MSCs proliferating under low Wnt catenin exhibited

  2018-10-20

  

  Moreover, MSCs proliferating under low Wnt/β-catenin exhibited higher expression of pluripotency genes such as Oct-4, Sox-2, and Nanog (Greco et al., 2007; Tsai et al., 2012), indicative of a more primitive state, whereas the Monastrol exhibited more committed osteoblast-like properties under high

• ptio Osteoarthritis OA is a common joint disease associated

  2018-10-20

  

  Osteoarthritis (OA) is a common joint disease associated with articular cartilage degeneration. To improve the therapeutic options of OA, tissue engineering based on the use of hBMSCs has become prominent; however, the presence of inflammatory cytokines, such as interleukin-1β (IL-1β), during the ch

• br Materials and methods br

  2018-10-20

  

  Materials and methods Author disclosure statement Acknowledgments We thank Muscle Tissue Culture Collection (MTCC) for providing the sample. The Muscle Tissue Culture Collection is part of the German network on muscular dystrophies (MD-NET, service structure S1, 01GM0601) and the German net

• Human ESC culture and processing were

  2018-10-20

  

  Human ESC culture and processing were performed in a grade A tissue culture cabinet in a grade B clean room environment monitored for particulate and microbiological contamination during cell processing in accordance with Rules and Guidance for Pharmaceutical Manufacturers and Distributors — The Ora

• The expression of T BRY

  2018-10-20

  

  The expression of T (BRY), taken as a marker of precursors of all mesodermal tissues, was here induced through the activation of the canonical Wnt signalling which has been identified as an inducer for the primitive streak. A novel GSK3β inhibitor compound, active at a lower concentration than that

• Following from our prior research

  2018-10-20

  

  Following from our prior research to derive new hESC lines under increasingly defined culture conditions (Fletcher et al., 2006) we sought to establish a facility within which our experience and evolving practice and reagents could be implemented to a GMP and professionally accredited standard. Her

• br Materials and methods br Author disclosure

  2018-10-20

  

  Materials and methods Author disclosure statement Acknowledgments This study was supported by fund from National Medical Research Council (NMRC) of Singapore, the Translational Clinical Research (TCR) award (NMRC/TCR/013-NNI/2014) and STaR award (NMRC/STaR/014/2013). We thank Ms. Fiona Seti

• Several studies have reported the existence of rare CD

  2018-10-20

  

  Several studies have reported the existence of rare CD34− HSCs upstream of the major population of CD34+ HSCs in the human hematopoietic hierarchy (Anjos-Afonso et al., 2013; Bhatia et al., 1998). Interestingly, the first HSCs found in the human embryo are CD34+ and give rise exclusively to a CD34+C

• The results presented here sug http www surface antigen

  2018-10-20

  

  The results presented here suggest that HIF and MYC are antagonistic to each other in neurogenesis. While others have suggested that this could be the case in other types of EHop-016 (Koshiji et al., 2004; Yoon et al., 2010), the mechanism proposed here is distinct. We found that a portion of MYC t

• br Results br Discussion Pluripotent stem

  2018-10-20

  

  Results Discussion Pluripotent stem order Tozadenant must tightly control the balance between cell survival and death to prevent unfavorable mutations and to ensure genomic integrity. First, maintenance of genomic stability must be particularly stringent, because any genetic alterations in pl

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