• The absolute requirement for substrate prephosphorylation

  2022-03-10

  

  The absolute requirement for substrate prephosphorylation raised the possibility that short phosphorylated peptides might serve as selective substrate competitive inhibitors. A set of phosphorylated peptides patterned after known GSK-3 substrates was generated and shown to inhibit GSK-3 in vitro in

• The differential tissue and ligand dependent signaling

  2022-03-09

  

  The differential tissue- and ligand-dependent signaling described here has important implications for the therapeutic potential of synthetic GPR109A agonists for the treatment of atherosclerosis. The failure of MK-0354, a biased, partial GPR109A agonist, to activate signaling pathways upstream of va

• Variants of NEIL were also analysed in Primary sclerosing ch

  2022-03-09

  

  Variants of NEIL1 were also analysed in Primary sclerosing cholangitis (PSC) and cholangiocarcinoma (CCA) patients by Forsbring et al. to identify effect of variants on these diseases. Four variants were identified i.e., one earlier validated (G83D) and three novel (E181K, H275, R339W). E181K was fo

• Lamina II SG spinal cord neurons play

  2022-03-09

  

  Lamina II (SG) spinal cord neurons play an important role in regulating nociceptive input from the periphery [20,21]. Moreover, lamina II neurons are concentrated with glycinergic or GABAergic inhibitory interneurons. Therefore, it is possible that β-alanine might modulate nociceptive transmission i

• br Introduction Anthocyanidins and anthocyanins glycosides o

  2022-03-09

  

  Introduction Anthocyanidins and anthocyanins (glycosides of anthocyanidins) are flavonoid phenolic compounds that are among the most common types of plant pigments [1]. They typically are responsible for the red, orange, blue, and violet colors in flowers, fruits, and vegetative tissues [1], [2].

• Although the ramifications of non additive

  2022-03-09

  

  Although the ramifications of non-additive SAR are context-dependent, the knowledge that perturbations in one region of a chemical series are not synergistic with perturbations in another region of the same chemical series is clearly pertinent to any medicinal chemistry effort. In our experience, no

• In a series of experiments the clotrimazole concentration wa

  2022-03-09

  

  In a series of experiments, the clotrimazole concentration was varied and the NSVDC channel conductances were calculated from Eq. (1) to obtain the dose-response relation (Fig. 3). The data were fitted to the Michaelis–Menten-type activation curve (Eq. (3)) and gave an EC50 value of 14 μM and a dose

• Moreover after the initial bleaching of the

  2022-03-09

  

  Moreover, after the initial bleaching of the fluorescent molecules in the targeted cell exposed to laser illumination, the neighboring reservoir Arotinoid Acid are expected to give in return new fluorescent ones if the cells are coupled together by gap junction channels. This supposes that the leve

• We identified three genes KEAP NAA

  2022-03-09

  

  We identified three genes—KEAP1, NAA38, and ABCC1/MRP1—as negative regulators of glutathione abundance in human cells. Like KEAP1, NAA38 appears to regulate NRF2 stability, as NAA38 deletion increased NRF2 protein levels and the expression of NRF2 target genes. NAA38 is a component of the NatC N-ter

• br STAR Methods br Acknowledgments We

  2022-03-09

  

  STAR★Methods Acknowledgments We would like to thank V. Gladyshev (Harvard), H. Kornblum (UCLA), L. Greene (Columbia), and J. Baraban (Johns Hopkins) for constructive comments to the project and manuscript. We thank L. Gross and A. Kumar for assistance with editing. We thank L.M. Gerber and Z.

• The investigation in vitro revealed that aldolase as

  2022-03-09

  

  The investigation in vitro revealed that aldolase, as well as FBPase, has affinity to α-actinin, one of the structural protein of the Z-line (Rakus et al., 2003a, Mamczur et al., 2005). Therefore, the existence of in vivo heterologous complex, consisting of aldolase, FBPase and α-actinin has been po

• In human cancers it has been

  2022-03-09

  

  In human cancers, it has been identified that FOXC2-AS1 functions as an oncogenic RNA. For instance, in osteosarcoma, FOXC2-AS1 regulates the expression of FOXC2 at the transcription and post-transcription levels to promote doxorubicin resistance by facilitating ABCB1 expression (C.L. Zhang et al.,

• ABT199 PKC s effect on quantal size may involve regulation o

  2022-03-09

  

  PKC’s effect on quantal size may involve regulation of endocytotic protein components responsible for mediating kiss-and-run exocytosis. There is a growing body of evidence to suggest that canonical endocytotic proteins—dynamin, amphiphysin, syndapin, and others—may play a role in modulating fusion

• Myocardial growth and maturation is regulated in part by sig

  2022-03-08

  

  Myocardial growth and maturation is regulated in part by signals from the underlying endocardium (Brutsaert, 2003, de la Pompa and Epstein, 2012, Rentschler et al., 2010). More generally, endothelial Quercitrin play an increasingly appreciated role in instructing organogenesis by providing inductive

• IL had marked effects on the inflammatory

  2022-03-08

  

  IL-33 had marked effects on the inflammatory response in human adipocytes beyond GPR84, with a substantial stimulation of the expression of a selected group of cytokine and chemokine genes. Expression of IL1B, a co-member of the IL-1 superfamily, was strongly up-regulated by IL-33, as was IL6 and CX

11555 records 173/771 page Previous Next First page 上5页 171172173174175 下5页 Last page