• Subsequently BAs are secreted in the portal vein by the

  2021-11-09

  

  Subsequently, BAs are secreted in the portal vein by the heterodimeric organic solute transporter OSTα/β [15]. At this level, BAs are transported back to the liver, where the great majority is reabsorbed by the sodium (Na)-Taurocholate Cotransporter Protein (NTCP) and organic anion transporting pol

• This excellent tolerability is especially interesting in

  2021-11-09

  

  This excellent tolerability is especially interesting in the light of the fact that intravenous administration of liposomal ponatinib was predicted to yield much higher plasma concentrations as compared to the orally administered free drug. In addition, liposomal drug dose in absolute numbers was te

• Till date the first line treatment

  2021-11-09

  

  Till date, the first line treatment of T2DM is oral metformin followed by oral sulfonylureas, dipeptidyl peptidase-IV-inhibitors, and TZDs. As the disease progresses, injectable glucagon-like peptide-I analogues or ultimately insulin become necessary to maintain glycaemic control. Despite the establ

• br Acknowledgments br The study was funded by the

  2021-11-09

  

  Acknowledgments The study was funded by the European Commission FP7-project Beta-JUDO (Grant 279153), and Swedish Diabetes Association (Grant DIA 2013-043) and Family Ernfors Foundation (Grant 150430). Free fatty neuron specific enolase receptors (FFARs) represent a family of G-protein coup

• Pharmacological inhibition of PKR seems to

  2021-11-09

  

  Pharmacological inhibition of PKR seems to be an interesting strategy for revealing the role of PKR in oxytosis and ferroptosis. The oxindole/imidazole derivative C16 was identified by screening a library of 26 different ATP-binding site-directed inhibitors of varying structure that is more selectiv

• Recent findings of us suggest that

  2021-11-09

  

  Recent findings of us suggest that compounds that inhibit both FAAH and TRPV1 may be more efficacious in pain relief than those targeting only one such protein. As continuation of our efforts to identify new molecules able to target simultaneously both FAAH and TRPV1 receptors, we hypothesized that

• br Transportation from TGN toward

  2021-11-09

  

  Transportation from TGN toward plasma membrane The insulin molecules are packaged along with other molecules such as C-peptides, amylin, Zn2+, ATP and GABA in synaptic-like macrovesicles (SLMVs, with the diameters of 50–100 nm) and large dense core vesicles (LDCVs, with the diameters of 200–500 n

• br Results br Discussion In

  2021-11-09

  

  Results Discussion In this study, six new T30695 variants were synthesized with the acyclic R or S glycerol linker instead of H-Ser-OH unit at 4, 8 or 12 T residue. Based on our previous studies on TBA-GQ, this type of modification should provoke local changes in GQ conformations in the final

• br Introduction Ovarian cancer patients

  2021-11-09

  

  Introduction Ovarian cancer patients have the highest mortality rate amongst patients with gynecologic cancers. The 10-year survival rate of ovarian cancer patients is in BRCA1/2, which is related to hereditary breast and ovarian cancer (HBOC) syndrome. As a new molecular targeted therapy for HG

• The fibulins are a newly abundantly in the basement

  2021-11-08

  

  The fibulins are a newly abundantly in the basement membrane of blood vessels. Among them, fibulin-1 is essential for elastin polymerization. Tropoelastin cannot be assembled into mature elastin fibrils without the functional fibulin-1. In adult blood vessels, pronounced fibulin 1 deposition can be

• In the present study we focused on a

  2021-11-08

  

  In the present study, we focused on a role of the C-terminal segment in GCAP2 using two chimeric proteins, in which the C-terminal segment of GCAP2 was either replaced by the corresponding sequence of recoverin (chimera GR) or transferred into recoverin (chimera RG). We have monitored Ca-dependent c

• Acknowledgments This research was supported by the Korea Res

  2021-11-08

  

  Acknowledgments This research was supported by the Korea Research Institute of Chemical Technology (KRICT) funded by the Ministry of Science, ICT & Future Planning (KK1703-G00, KK1707-C05, SI1707-02, KK-1607-C09, and SKO1707C05) and a grant of the Korea Health Technology R&D Project through the Kor

• In an immunohistochemical analysis of gastric cancer samples

  2021-11-08

  

  In an immunohistochemical analysis of 117 gastric cancer samples, reduced Cx43 and E-cadherin expression were shown to contribute to the development of primary gastric cancer; however, increased Cx43 and E-cadherin expression contributed to lymph node metastasis [13]. In primary urothelial Betametha

• In perimenstrual catamenial epilepsy there is emerging evide

  2021-11-08

  

  In perimenstrual catamenial epilepsy, there is emerging evidence to suggest that P withdrawal plays a key role in seizure exacerbations occurring around the time of menstruation (Backstrom et al., 1984, Bonuccelli et al., 1989, Scharfman and MacLusky, 2006). The mechanisms underlying ovarian cycle-r

• br Experimental br Results and discussions br Conclusion

  2021-11-08

  

  Experimental Results and discussions Conclusion Notes Introduction The noncanonical DNA structures that is, i-motif [[1], [2], [3], [4], [5], [6], [7], [8], [9]] and G-quadruplex [[10], [11], [12], [13], [14]] have recently been carefully studied using either experimental or computati

15808 records 532/1054 page Previous Next First page 上5页 531532533534535 下5页 Last page