• Following Duncan as a ritualized site Tyne Cot

  2020-12-23

  

  Following Duncan (1995), as a ritualized site Tyne Cot provides an opportunity for individual tourists to conduct their own acts of remembrance (Edensor, 2000, Iles, 2006). The analysis has also shown that individual acts of writing particular words and phrases in the visitor books are socially shar

• Since protein kinase CK has

  2020-12-23

  

  Since protein kinase CK2 has over 300 known substrates we examined if the inhibitory effects described above could also be detected using another substrate. Therefore, we employed the synthetic peptide RRRADDSDDDDD which is often used in CK2 inhibitory studies. Quite contrary to the phosphorylation

• IAA sensitive Cl channels were

  2020-12-22

  

  IAA-94-sensitive Cl channels were shown to mediate cardioprotection due to IPC (Diaz et al., 1999) and cyclosporine A (Diaz et al., 2013). CLIC-like channel activity was also observed in cardiac mitoplast (Misak et al., 2013) but the molecular identity of these intracellular Cl channels and their pr

• Rat pheochromocytoma PC cells have been widely

  2020-12-22

  

  Rat pheochromocytoma PC12 cells have been widely used as a cell system to study intracellular signaling leading to neurite outgrowth. The advantages of using PC12 cells in the CHK studies are the fact that they naturally express the rat form of CHK and the observation that down-regulation of CHK fun

• br Conclusion The role of DNA PK target in

  2020-12-22

  

  Conclusion The role of DNA-PK target in DNA DSB repair renders this LX7101 HCL kinase of great medicinal interest in cancer chemotherapy especially the cancer types of linked to DNA defects. Due to the absence of 3D DNA-PK target structure, different ligand-based methods were applied for design

• br Experimental section br Results and discussion

  2020-12-22

  

  Experimental section Results and discussion Conclusions In conclusion, we have presented an autocatalytic recycling amplification electrochemical biosensing platform for simple, rapid and ultrasensitive detection of MTase activity by combining methylation-sensitive restriction endonuclease

• DNMT is the dominating enzyme responsible for maintenance of

  2020-12-22

  

  DNMT1is the dominating enzyme responsible for maintenance of the DNA methylation pattern and the primary enzyme responsible for copying methylation patterns following DNA replication (Moore et al., 2013). DNMT1 maintains the mitotic inheritance of the original methylation pattern in a cell lineage d

• These findings further extend our knowledge of how P and

  2020-12-22

  

  These findings further extend our knowledge of how P4 and/or E2 can mediate anxiety and fear responses. Female rats in behavioral estrous and ovx rats administered systemic P4 and/or E2 demonstrated significantly less anxiety in the open field and/or elevated plus maze, compared to diestrous rats, a

• aa-utp australia br Experimental All starting materials and

  2020-12-22

  

  Experimental All starting materials and reagents were purchased from Sigma-Aldrich, Merck and Loba Chemie. Thin layer chromatography (TLC) was performed on silica gel G60 F254 (Merck) plates and eluted with the mobile phase n-hexane: ethyl acetate (70:30%v/v). Melting points were recorded on auto

• LY 255283 Studies of Jelski and Szmitkowski show that differ

  2020-12-22

  

  Studies of Jelski and Szmitkowski show that differences of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) activity between LY 255283 of many cancers and healthy tissue may be one of the factors intensifying carcinogenesis [7]. Moreover, changes of ADH and ALDH activity in cancer cells

• this br Clinical studies br Practical implications for young

  2020-12-22

  

  Clinical studies Practical implications for young women Conclusion Research on the oncogenic mechanism of hormones has advanced dramatically in the latter years. The finding that progestogens are more powerful determinants of risk than estrogens in breast cancer has been added to advances i

• Here although tibolone reduced the expression of inflammator

  2020-12-22

  

  Here, although tibolone reduced the expression of inflammatory genes such as IL6, IL1β, TLR4 and MIR155-3p, in the presence of PA stimulation, it increased the expression of TNF gene. It should be noted that TNF has pleiotropic effects in the CNS, therefore its increased expression does not always i

• Since the dideoxy analogues and served as

  2020-12-22

  

  Since the 1,2-dideoxy analogues, and , served as substrates for TgTCEA and TgTCEB, respectively, with the higher affinity (lower ) and lower turnover number (lower ) than their authentic substrates, PosA and PosB (such trend was more evident on analogue for TgTCEB than on analog for TgTCEA), an i

• br Material and methods br Results br Discussion Isolated ce

  2020-12-22

  

  Material and methods Results Discussion Isolated CGRP (rat) have several potential advantages over other in-vitro approaches, such as expression of properties similar to their site of origin including the possibility of bidirectional transmembrane transport and exposure. Furthermore, they

• Most xenobiotics undergo biotransformation before being excr

  2020-12-22

  

  Most xenobiotics undergo biotransformation before being excreted. Such biotransformation is classified into two phases. In the first phase, the lipophilic substrate is oxidized by the cytochrome P-450 (CYP450) enzyme system, which introduces a single oxygen ciprofloxacin into the molecule (Moutou et

15808 records 713/1054 page Previous Next First page 上5页 711712713714715 下5页 Last page