• Diverticulosis has become a common condition in developed

  2018-10-22

  

  Diverticulosis has become a common condition in developed countries, and its prevalence increases with age. Diverticulosis may occur anywhere in the gastrointestinal tract, with the sigmoid region accounting for > 85% of the cases. Diverticulitis, an infection of the diverticula, can lead to hemorrh

• br Fortification with seed oil

  2018-10-22

  

  Fortification with seed oil containing unsaturated fatty acids and phytosterols Plant sterols compromise a group of compounds which is the focus of research at the moment. They decrease cholesterol focal adhesion kinase and may thus protect against atherosclerosis [74,75]. Furthermore, they may h

• These results showed that the phenolic

  2018-10-22

  

  These results showed that the phenolic extracts scavenged the radicals and prevented the oxidation of the membrane lipids and DCFH, thereby reducing the formation of DCF. DCF is formed from the reaction between DCFH trapped in the LY317615 and the ABAP-induced peroxyl radicals. The cellular antioxid

• br Materials and methods br Results br Discussion

  2018-10-22

  

  Materials and methods Results Discussion Obesity results when caloric intake exceeds energy expenditure, with an increase in adipocyte size or adipocyte number (Bjorntorp, 1974; Faust et al., 1978; Johnson et al., 1971, 1978; Yu et al., 1997). In the context of adipogenesis, development app

• adiponectin receptor There is a significant need

  2018-10-22

  

  There is a significant need to develop novel therapeutics to counter BoNT poisoning—especially postneuronal internalization (Hakami et al., 2010). However, there are currently no reliable, large-scale cell-based drug screening assays to facilitate such research. This is mainly due to a lack of relev

• To study this complex neuroprotective

  2018-10-22

  

  To study this complex neuroprotective pathway, a common endpoint needs to be identified. A potential pathway involves the regulation of the major cellular antioxidant glutathione. Glutathione biosynthesis, which begins with the import of cystine dimers through the cystine glutamate exchanger (System

• There are several reports that demonstrate roles

  2018-10-22

  

  There are several reports that demonstrate roles for Rad51 in addition to its participation in classical HR-mediated DSB repair. For example, in Saccharomyces cerevisiae that lack telomerase or certain telomere binding proteins, the telomeres can be maintained in rare survivors by alternative recomb

• One group has recently identified bone marrow BM residing ve

  2018-10-22

  

  One group has recently identified bone marrow (BM)-residing very small embryonic-like stem cells (VSELs) in both human and mouse as a putative nonembryonic source for PSCs (Drukała et al., 2012; Kucia et al., 2006b; Wojakowski et al., 2009; Zuba-Surma et al., 2011). Mouse VSELs have been characteriz

• To further determine the generality

  2018-10-22

  

  To further determine the generality of our finding that iPSCs harbor unique transversion-predominant point mutation profiles (Figure S2D, left), we analyzed previously reported point mutation profiles in 27 different iPSC lines that had been established by various methods, including retrovirus, plas

• The following are the supplementary data related to this art

  2018-10-22

  

  The following are the supplementary data related to this article. Acknowledgments The work in the author\'s laboratory is currently supported by the grants from NIH (GM093335), New York State (NYSTEM Contract# C026434) and American Heart Association (09SDG2400151). YS is partly supported by NIH

• The ubiquitously expressed FGF is the prototypic member

  2018-10-20

  

  The ubiquitously expressed FGF2 is the prototypic member of the paracrine group of human FGFs (Beenken and Mohammadi, 2009). Its endogenous expression is regulated at multiple levels including the alternative translation of polypeptides that eventually differ in size (18–34kDa), domain structure and

• Moreover MSCs proliferating under low Wnt catenin exhibited

  2018-10-20

  

  Moreover, MSCs proliferating under low Wnt/β-catenin exhibited higher expression of pluripotency genes such as Oct-4, Sox-2, and Nanog (Greco et al., 2007; Tsai et al., 2012), indicative of a more primitive state, whereas the Monastrol exhibited more committed osteoblast-like properties under high

• ptio Osteoarthritis OA is a common joint disease associated

  2018-10-20

  

  Osteoarthritis (OA) is a common joint disease associated with articular cartilage degeneration. To improve the therapeutic options of OA, tissue engineering based on the use of hBMSCs has become prominent; however, the presence of inflammatory cytokines, such as interleukin-1β (IL-1β), during the ch

• br Materials and methods br

  2018-10-20

  

  Materials and methods Author disclosure statement Acknowledgments We thank Muscle Tissue Culture Collection (MTCC) for providing the sample. The Muscle Tissue Culture Collection is part of the German network on muscular dystrophies (MD-NET, service structure S1, 01GM0601) and the German net

• Human ESC culture and processing were

  2018-10-20

  

  Human ESC culture and processing were performed in a grade A tissue culture cabinet in a grade B clean room environment monitored for particulate and microbiological contamination during cell processing in accordance with Rules and Guidance for Pharmaceutical Manufacturers and Distributors — The Ora

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