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Based on currently available knowledge autophagy supports ad
2024-06-26
Based on currently available knowledge, autophagy supports adipocytes development and differentiation. In animals with specific skeletal muscle CH5138303 sale of Atg7, reduced adipogenesis was shown. In rodents, autophagy was decreased in adipose tissue of animals fed with high-fat diet (HFD). In c
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Cancer cells manifest characteristic abnormal growth propert
2024-06-26
Cancer lrrk2 manifest characteristic abnormal growth properties accompanying clonal evolution of cells displaying progressively increasing genomic instability capable of invasion and metastasis to distant organ sites. With the emerging knowledge about the role of known oncogene and tumor suppressor
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To test the compounds metabolic stability we measured
2024-06-26
To test the compounds metabolic stability, we measured the half-life of compounds and in mouse hepatic microsomes (1mg/mL) and found them to have modest stability, with half-lives of 7.5 and 2.9min respectively, indicating these compounds may be unsuitable for studies. In order to gain structura
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Another important question concerns the mechanism
2024-06-26
Another important question concerns the mechanism by which a polyubiquitinated substrate is released from the Cdc48 complex and passed on to downstream components, such as the proteasome. There are at least three proposed models. In the first, a ubiquitinated substrate is transferred by ubiquitin-bi
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We also measured macrophage infiltration and CLS
2024-06-26
We also measured macrophage infiltration and CLS presence in peri-gonadal AT from db/db mice and controls. CLS are morphological features within AT that are accurate indicators of adipocyte death and macrophage infiltration [56]. An earlier study showed that CLS macrophages account for >90% of the t
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br Introduction Arginase deficiency is a rare metabolic diso
2024-06-26
Introduction Arginase deficiency is a rare metabolic disorder resulting from a loss of arginase 1 (ARG1), the final enzyme in the urea cycle, which is the major pathway for the detoxification of ammonia in terrestrial mammals. ARG1 is expressed most prevalently in hepatocytes and red blood cells.
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It has been proven that
2024-06-26
It has been proven that genetic polymorphisms can play an important role in development of hypertension and CVDs. In a Turkish population-based study, it was found that the APLNR gene (rs948847-A445C) polymorphism was not associated with coronary artery disease (CAD), but it was shown to be related
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130 ml mg br Materials and methods br Results br
2024-06-26
Materials and methods Results Discussion Pulmonary fibrosis is a progressive and chronic lung disease and its typical features include 130 ml mg proliferation, epithelial injury, chronic interstitial inflammation, increased extracellular matrix (ECM) production, and collapse of alveoli, al
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br Conclusions and perspectives In
2024-06-26
Conclusions and perspectives In view of the evidences supporting that neomycin sulfate MAS receptors mediate the effects of AT1 antagonists (Iwai et al., 2012, Ohshima et al., 2014, Pernomian et al., 2015, Schuchard et al., 2015), the prime targets from the perspectives on future directions in t
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There are several reports providing evidences that functiona
2024-06-26
There are several reports providing evidences that functional and mechanistic connection between Sirt1 and LKB1/AMPK in metabolic regulation [26], [32], [33]. It has been reported that the deacetylation of LKB1 by Sirt1 is one of the determining factors of the subcellular localization of LKB1. In ag
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br The role of LOX plays in autophagy
2024-06-25
The role of 12/15-LOX plays in autophagy Autophagy is a process by which cellular material is delivered to lysosomal to degrade the damaged organelles and proteins to facilitate nutrient recycling (Towers and Thorburn, 2016). There has been characterized three types of autophagy-macroautophagy, m
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br Materials and methods br
2024-06-25
Materials and methods Results Table 1 presents the metabolic phenotype of obese minipigs. After 60 d of HFHS feeding, minipigs not only showed an increased body weight (+45%), but also a perturbed Gemcitabine HCl homeostasis, with higher insulin levels (about +2-fold), HOMA-IR (+5.5-fold), and
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br Conclusions br Conflict of interest br Introduction Plant
2024-06-25
Conclusions Conflict of interest Introduction Plants often encounter a series of abiotic stresses during the growth process, including high salinity, extreme temperatures and drought (Knight and Knight, 2001). Plants can adapt through ionic and osmotic homeostasis or osmotic adjustment, con
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An important observation in our study is the lack
2024-06-25
An important observation in our study is the lack of effect of paroxetine pretreatment alone on β2AR membrane expression, which suggests that paroxetine, and pharmacologic inhibition of GRK2 in general, does not directly induce changes in receptor dynamics. Rather, the decreased ligand-induced β-arr
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br Materials and methods br Results br Discussion In
2024-06-25
Materials and methods Results Discussion In this study, we have demonstrated that the adiponectin system (genes and proteins) is present in the porcine endometrium (epithelial glandular cells, luminal epithelial SJB3-019A and stromal cells) and myometrium (longitudinal and circular muscle l
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