• In advanced GIST patients where a

  2019-06-28

  

  In advanced GIST patients where a course of treatment of Imatinib is interrupted by disease progression, subsequent rechallenge with Imatinib restored tumor control in most patients. In the prospective BFR14 trial, 25 patients with disease progression after interruption of one year of treatment rest

• Funding secured by Not applicable Data collection Sheldon M

  2019-06-28

  

  Funding secured by: Not applicable. Data collection: Sheldon M. Singh, MD, Ramanan Kumareswaran, MD. Conflict of interest Acknowledgments Introduction Early repolarization pattern (ERP) is characterized by an elevation greater than 0.1mV of the junction between the end of the QRS complex

• br We have reviewed the issues

  2019-06-28

  

  We have reviewed the issues and arguments presented by Wang et al. In fact, we have well-clarified these issues in “Discussion” section of our original article. The aim of our study was to investigate the expression of maternal antineuronal carnitine palmitoyltransferase and their role in childh

• In conclusion a rare KCNE D

  2019-06-28

  

  In conclusion, a rare KCNE1-D85N polymorphism may modify the LQTS phenotype in combination with other pathogenic LQTS-related gene mutations. Disclosures Conflict of interest Acknowledgments Introduction Atrial fibrillation (AF) is observed in 10–30% of patients with symptomatic Camptot

• br Conflict of interest br Introduction

  2019-06-28

  

  Conflict of interest Introduction Case report Discussion Dextrocardia is commonly associated with situs inversus totalis (incidence: 2 in 10,000 individuals) and rarely associated with situs solitus (incidence: 1 in 20,000 individuals). While associated cardiac anomalies are seen in appr

• One study reported the role of the Purkinje system with

  2019-06-28

  

  One study reported the role of the Purkinje system with respect to the relationship between the septum and HCM-related VT. Santangeli et al. reported that patients with HCM also often have His-Purkinje conduction-related septal abnormalities, and bundle branch block often develops as part of the nat

• Introduction Ewing s sarcoma ES is a high grade

  2019-06-28

  

  Introduction Ewing\'s sarcoma (ES) is a high-grade neoplasm representing the second most common primary bone malignancy in both children and adults. With a peak incidence at 15 years, this disease accounts for 2% of childhood cancers [1–3]. ES is defined as a bone tumor which may occur at any site

• In summary we have established an animal model of

  2019-06-28

  

  In summary, we have established an animal model of human NB bone metastasis in which COX-2/PGE2 plays a critical role. We provide pre-clinical data supporting the use of COX-2 inhibitors in the treatment of bone metastases in NB. Conflict of interest statement Introduction Desmoplastic fibrom

• br Discussion We describe an additional

  2019-06-28

  

  Discussion We describe an additional diagnosis to consider when BVT is identified. One of the proposed mechanisms of BVT include elevated intracellular calcium, causing delay after depolarization in anatomically separate parts of the conducting system. Baher et al. [1] proposed that two separate

• Evidence based interventions that are

  2019-06-27

  

  Evidence based interventions that are theory driven and accessible within the local culture are do-able and do not need to rely on imported interventions—especially when those are costly. Many bereaved children and youth reside in the chemical this article and have little recourse to good psychosoc

• Macrophages in bone metastasis main outstanding questions br

  2019-06-27

  

  Macrophages in bone metastasis – main outstanding questions: Conflict of interest statement Acknowledgements IV was supported by a generous grant from Weston Park Hospital Cancer Charity, Sheffield, UK. Introduction In recent years there has been increasing interest in the role of bone-ta

• br Discussion br Conclusions br Conflicts of

  2019-06-27

  

  Discussion Conclusions Conflicts of interest Introduction Catecholaminergic polymorphic ventricular tachycardia (CPVT) is induced by emotional stress or exercise in patients without organic heart disease and may be polymorphic or bidirectional (Fig. 1) [1–3]. This ventricular arrhythmia

• Induction of labor starting with cervical ripening

  2019-06-27

  

  Induction of labor starting with cervical ripening through the Foley catheter method has been a generally accepted technique and believed to be the safest method to manage pregnant women with an unfavorable Diperodon HCl molecular because it avoids exogenous uterine stimulants and relies on the loc

• Pharmacokinetics analysis of AT on SCID mice bear http

  2019-06-27

  

  Pharmacokinetics analysis of AT-406 on SCID mice bearing MDA-MB-231 tumors has shown that AT-406 achieves a maximum concentration in plasma between 1.5μM and 9.9μM, and a maximum concentration in tumor tissue between 0.5μM and 18.2μM, depending on the dose and administration route (intravenous versu

• Bone marrow resident Macs Osteomacs

  2019-06-27

  

  Bone marrow resident Macs (Osteomacs) are located in canopy-like structures in endosteal and periosteal surfaces, above osteoblasts [6]; osteoclasts result from the fusion of several myeloid osteoclast precursors [7]. Osteomacs constitute approximately 17% of the bone marrow 1-NM-PP1 and they diffe

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