• The elevation of JAG surface expression in

  2018-11-08

  

  The elevation of JAG1 surface expression in transitional ECs suggests that it plays a role in phenotypic transition of these cells. Overexpression of activated JAG1 cDNA in cultured human microvascular ECs activated a SMA-promoter driven luciferase and induced trans-differentiation to vascular smoot

• By continuously observing hundreds of individual HSCs

  2018-11-08

  

  By continuously observing hundreds of individual HSCs and their progeny during differentiation, we can exclude a change in cell-cycle length in HSPCs upon GADD45G expression, which was unexpected, because studies on solid tissue Tenofovir Disoproxil Fumarate reported a G2/M cell-cycle arrest mediat

• br Results br Discussion Direct

  2018-11-08

  

  Results Discussion Direct reprogramming of human somatic cftr channel into functional neurons has been proposed as an alternative strategy to obtain patient-specific neurons for disease modeling, drug screening, and toxicity tests (Qiang et al., 2014). Indeed, this approach offers some advanta

• Previously our group has isolated human embryonic stem cells

  2018-11-08

  

  Previously, our group has isolated human embryonic stem K03861 Supplier (ESCs) whose pluripotent state is maintained in vitro by exogenous growth factor signaling, particularly fibroblast growth factor (FGF), insulin or insulin-like growth factor, and transforming growth factor (Bendall et al., 200

• To determine whether overexpression of Sca

  2018-11-08

  

  To determine whether overexpression of Sca-1 in progenitor cells residing in the bulge and upper isthmus could function as an initiating event, Rosa:Cre mice and control littermates were treated with TPA only. This treatment resulted in very few papillomas that quickly regressed and there was no sig

• br Introduction The adult prostate gland contains a simple c

  2018-11-08

  

  Introduction The adult prostate gland contains a simple columnar epithelium composed of luminal secretory and underlying basal XL 184 with a scarce neuroendocrine cell component. These epithelial cells are derived from a rare, relatively quiescent stem cell population that maintains glandular ho

• miRNAs are known to regulate the expression of multiple targ

  2018-11-08

  

  miRNAs are known to regulate the expression of multiple targets via binding to 3′ UTR. Our finding that the miR-29 family regulates global DNA methylation and demethylation adds another role to the list of common regulatory roles of miRNAs. The miR-29 family was known to regulate ECM proteins in phy

• miRNAs often take part in fine tuning major signaling pathwa

  2018-11-07

  

  miRNAs often take part in fine-tuning major signaling pathways (Inui et al., 2010). The interaction between Notch signaling and an miRNA, namely miR-9a, was first described in Drosophila in the context of sensory organ precursor development (Li et al., 2006). More recently, the existence of an inter

• br Introduction Newborn neurons are

  2018-11-07

  

  Introduction Newborn neurons are continuously generated throughout life in several areas of the mammalian brain, including the subgranular zone (SGZ) of the hippocampal dentate gyrus (Imayoshi et al., 2008; Palmer et al., 1997; Zhao et al., 2008). Adult hippocampal neurogenesis is essential for n

• Ara jo et al highlights that the progressive

  2018-11-07

  

  Araújo et al. (1992) highlights that the progressive targeting of the Brazilian MT exports in the late 1980s towards developed countries such as USA, Germany, Italy and Canada shows that the industry made ​​a significant competitive effort. The growth of the intra-industry trade, the diversification

• The diagnosis of OSAS is one of the

  2018-11-07

  

  The diagnosis of OSAS is one of the key problems in this field. Although polysomnography is considered as the gold standard for the diagnosis of OSAS [1], this method is not yet widely available due, probably, to its high cost. Thus, some attempts have been made to develop self-report measures based

• There is evidence of an

  2018-11-07

  

  There is evidence of an association between bruxism and tension, stress, and emotional disturbance [33]; however the influence of socioeconomic status is less clear [4,25]. Of note, our study showed that the presence of bruxism was associated with higher income and socioeconomic class as well as inc

• Con el n mero de la revista

  2018-11-07

  

  Con el número 395 de la revista concluimos un año más de publicar temas económicos coyunturales de actualidad. Así, iniciamos con Carlos Guerrero de Lizardi, mediante un análisis de “Un enfoque imperfecto para medir la distribución de la riqueza financiera y no financiera de los hogares en México 1

• HLA transgenic mice are widely used to model the human

  2018-11-07

  

  HLA-transgenic mice are widely used to model the human T cell response in mice. We focused the present study on the HLA B*0702 allele, which is associated with strong T cell response in terms of magnitude and breath (Weiskopf et al., 2013), thereby allowing us to test the role of multiple cross-reac

• We also compared protein abundances

  2018-11-07

  

  We also compared protein abundances in primary Merlin-deficient human meningioma leukotriene against human meningeal cells, and primary human schwannoma cells against primary human Schwann cells. We identified numerous novel upregulated and downregulated proteins and phospho-proteins, performed Gen

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